HZB-MX related Publications and Structures

This page lists 1624 publications with direct reference to 4300 PDB structures (out of 5189 released) citing the X-ray diffraction experiments at the HZB-MX beamlines. The sort order is by electronic publication date, with the latest one at the top.

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Publications and Structures from Bessy-MX

• Mismetallation reveals metal tolerance and enhanced stability of human deoxyhypusine hydroxylase
  Zakaszewski, D.; Wilk, P.; Wator-Wilk, E.; Grudnik, P.
  Int J Biol Macromol (384), 154732-154732 (2026)
  DOI: 10.1016/j.ijbiomac.2026.154732
  PubMed ID: 42829144
  

• New Structures of Human Formylglycine-generating Enzyme Reveal Features Important for Catalysis, Disease and Structure-based Drug Design
  Kowal, J.L.; Alam, S.; Radhakrishnan, K.; Dickmanns, A.; Neumann, P.; Schlotawa, L.; Ficner, R.; Dierks, T.; Rudolph, M.G.; Niemann, H.H.
  J Mol Biol (438), 169987-169987 (2026)
  DOI: 10.1016/j.jmb.2026.169987
  PubMed ID: 42580400
  

• Structural and Mechanistic Insight into Oxidative Ring Opening Catalyzed by L-DOPA Extradiol Dioxygenase from Beta vulgaris
  Hapke, M.; Kluza, A.; Seweryn-Ozog, K.; Andrys-Olek, J.; Jahan, F.; Kachhap, S.; Milaczewska-Kregiel, A.; Tataruch, M.; Freindl, K.; Korecki, J.; Sarewicz, M.; Osyczka, A.; Borowski, T.
  ACS Catal (2026)
  DOI: 10.1021/acscatal.6c06086
  

• Integrative structural modelling reveals the human Mic60-Mic19 subcomplex as a diffusion barrier in mitochondria
  Nathanail, E.; Rolando, E.; Ruwolt, M.; Zaporozhets, I.; Liu, F.; Clementi, C.; Daumke, O.
  Nat Commun (17) (2026)
  DOI: 10.1038/s41467-026-77869-3
  PubMed ID: 42800801
  

• Self-S-sulfonation in a bacterial persulfide dioxygenase mediates thiol persulfide detoxification
  Campecino, J.O.; Costa, S.S.; Pires, I.D.S.; Walsh, B.J.C.; Trinidad, J.C.; Kannoujia, J.; Poore, A.T.; Van Stappen, C.; Gonzalez-Gutierrez, G.; Archer, M.; Machuqueiro, M.; Brito, J.A.; Giedroc, D.P.
  Commun Chem (2026)
  DOI: 10.1038/s42004-026-02216-y
  

• Structure of recombinant Thermoascus aurantiacus xylanase TaXyn10 with an authentic N-terminal pyroglutamate
  Mijatovic, J.; Mueller, U.; Weiss, M.S.; Lennartz, F.
  Acta Crystallogr F Struct Biol Commun (82), 329-335 (2026)
  DOI: 10.1107/S2053230X26009155
  PubMed ID: 42771010
  

• Cycloserine inhibits glutamate decarboxylase from Mycobacterium tuberculosis
  Snasel, J.; Dostal, J.; Tupec, M.; Bulvas, O.; Pichova, I.
  J Enzyme Inhib Med Chem (41), 2707854-2707854 (2026)
  DOI: 10.1080/14756366.2026.2707854
  PubMed ID: 42765272
  

• Plant NAOGAT (ArgJ) Structure Reveals Mechanism of Ornithine Biosynthesis, Preference for Acetylornithine and Susceptibility to Mangotoxin
  Nielipinski, M.; Pietrzyk-Brzezinska, A.J.; Twarda-Clapa, A.; Sekula, B.
  Plant Cell Environ (2026)
  DOI: 10.1111/pce.70891
  PubMed ID: 42765862
  

• Fragment-Based Covalent Targeting of Lysines at the Allosteric Latch Site of SHP2
  Di Lorenzo, V.; Csorba, N.; Szabo, R.; Kollar, L.; Roske, Y.; Randelovic, I.; Balazs, K.; Szalai, T.V.; Efrem, N.L.; Mihalovits, L.; Imre, T.; Simon, J.; Tovari, J.; Nazare, M.; Daumke, O.; Abranyi-Balogh, P.; Keseru, G.M.
  J Med Chem (69), 21955-21971 (2026)
  DOI: 10.1021/acs.jmedchem.6c01030
  

• N4BP1 uses tandem KH domains to associate with EDC4 and mRNA decapping factors in P-bodies
  Pilat, P.; Garg, A.; Heinemann, U.; Wilamowski, M.; Jura, J.
  Commun Biol (9) (2026)
  DOI: 10.1038/s42003-026-10938-x
  PubMed ID: 42754686
  

• Cell type-selective targeting by heterobifunctional protein binders via in-cell enrichment
  Bulldan, A.; Zheng, M.; Meyners, C.; Purder, P.L.; Krieger, J.; Dreizler, J.K.; Geiger, T.M.; Repity, M.L.; Lein, M.H.; Quist-Lokken, I.; Tewes, N.; Smith, E.R.; Schwab, K.; Fischer, M.; Schwalm, M.P.; Dey, R.; Aswathaman Sivashanmugam, S.; Schlesiger, S.; Moniot, S.; Knapp, S.; Hartung, I.V.; Holien, T.; Loewer, A.; Hausch, F.
  Nat Commun (17) (2026)
  DOI: 10.1038/s41467-026-77460-w
  PubMed ID: 42754590
  

• Crystal structure of human NIF3-like protein reveals dynamic hexameric assembly with a single divalent metal binding site
  Wator-Wilk, E.; Zak, K.; Wilk, P.; Kochanowski, P.; Maslanka, A.; Skalniak, L.; Grudnik, P.
  FEBS J (2026)
  DOI: 10.1111/febs.70724
  PubMed ID: 42741873
  

• A glycosaminoglycan-binding LecA-like lectin from Xenorhabdus nematophila: structural and biophysical characterization
  Korsak, M.; Komarek, J.; Houser, J.; Pongener, I.; Miller, G.J.; Wimmerova, M.
  Carbohydr Polym (388), 125557-125557 (2026)
  DOI: 10.1016/j.carbpol.2026.125557
  PubMed ID: 42493122
  

• KAT6A-inhibitor co-crystal structures: tackling a challenging crystallization target via two alternative approaches
  Puetter, V.; Bouche, L.; Nowak-Reppel, K.; Ferrara, S.J.; Gradl, S.N.; Korr, D.; Strathdee, C.A.; Ter Laak, A.; Hillig, R.C.
  Acta Crystallogr D Struct Biol (82), 1111-1124 (2026)
  DOI: 10.1107/S2059798326008545
  PubMed ID: 42657771
  

• omega-Hydroxyacid Dehydrogenases From Clostridium viride: Iron-Containing Biocatalysts With Biotechnological Potential
  Begic, T.; Hill, J.; Stitzel, J.L.; Knauer, L.; Schunemann, V.; Raschle, M.; Martins, B.M.; Pierik, A.J.
  Chembiochem (27), e70511-e70511 (2026)
  DOI: 10.1002/cbic.70511
  PubMed ID: 42626997
  

• Deciphering the evolutionary origin of the enantioselectivity of short-chain dehydrogenases from plants toward 1-borneol
  Zuson, J.; Helmer, C.P.O.; Di Geronimo, B.; Chanique, A.M.; Kavciakova, K.; Teijeiro-Juiz, R.; Brickel, S.; Ramirez Molina, N.; Drienovska, I.; Kracher, D.; Gaucher, E.A.; Kamerlin, S.C.L.; Loll, B.; Kourist, R.
  Nat Commun (17) (2026)
  DOI: 10.1038/s41467-026-76435-1
  PubMed ID: 42744776
  

• Changes in the structure of mitochondrial processing peptidase driven by adaptation to anaerobiosis
  Samad, A.; Ptackova, J.; Motlova, L.; Kucera, T.; Novak, P.; Barinka, C.; Cerny, J.; Kutejova, E.; Cianci, M.; Janata, J.; Tachezy, J.
  Int J Biol Macromol (372), 153058-153058 (2026)
  DOI: 10.1016/j.ijbiomac.2026.153058
  PubMed ID: 42303018
  

• Functional divergence and structural changes of Class IV histone deacetylases (HDACs) across the tree of life
  Novakova, Z.; Bartosova-Sojkova, P.; Kudlacova, J.; Baselious, F.; Kutilova, Z.; Jaklova, P.; Meleshin, M.; Motlova, L.; Schenkmayerova, A.; Vrkoslav, V.; Strnad, S.; Horacek, N.; Gruber, A.; Zacek, P.; Kroll, S.; Havlinova, B.; Ondrakova, M.; Tuckova, R.; Krunclova, T.; Cvacka, J.; Obornik, M.; Schutkowski, M.; Sippl, W.; Barinka, C.
  Mol Biol Evol (43) (2026)
  DOI: 10.1093/molbev/msag150
  PubMed ID: 42308148
  

• Customizing the structure of minimal TIM barrels to craft efficient de novo enzymes
  Beck, J.; Smith, B.J.; Kriegel, M.; Zarifi, N.; Freund, E.; Harsha, A.G.; Hartmann, J.; Chica, R.A.; Hocker, B.
  Nat Chem Biol (2026)
  DOI: 10.1038/s41589-026-02250-w
  PubMed ID: 42297966
  

• Probing 3-Amino-2H-Azaindazoles as Allosteric Inhibitors of the Protein Tyrosine Phosphatase SHP2
  Amoussa, M.; Efrem, N.L.; Li, F.; Guo, Z.; Roske, Y.; Frank, K.J.; Pach, S.; Wolf, C.A.; Bo, F.; Lesina, M.; Kintzel, M.; Alsalim, R.; Zeitz, V.; Csorba, N.; Radetzki, S.; Keseru, G.M.; Daumke, O.; Algul, H.; Wolber, G.; Li, J.; Nazare, M.
  ChemMedChem (21), e70341-e70341 (2026)
  DOI: 10.1002/cmdc.70341
  PubMed ID: 42289381
  

• The EF-hand domain of MINDY3 is a ubiquitin and RAD23 UBL-binding domain
  Armstrong, L.A.; McFarland, M.R.; O'Dea, R.; Krutyholowa, R.; Gorka, M.; Carroll, T.; Glatt, S.; Kulathu, Y.
  EMBO Rep (27), 3604-3631 (2026)
  DOI: 10.1038/s44319-026-00825-1
  PubMed ID: 42265305
  

• Identification of targetable epitope surfaces from the high resolution structure of the superantigen Staphylococcal enterotoxin L
  Klamm, E.; Curato, C.; Siewert, K.; Marino, S.F.
  Sci Rep (16) (2026)
  DOI: 10.1038/s41598-026-54870-w
  PubMed ID: 42265145
  

• Structural evolution of a fungal cell wall protein family for beta-glucan-binding and cell separation
  Schoppner, P.; Weitzel, V.; Veelders, M.; Korf, L.; Andras, J.; Wolf, K.; Bruckner, S.; Essen, L.-.O.; Mosch, H.-.U.
  mBio (17), e0353525-e0353525 (2026)
  DOI: 10.1128/mbio.03535-25
  PubMed ID: 42089631
  

• Correspondence on "Fortification of FeS Clusters Reshapes Anaerobic CO Dehydrogenase Into an Air-Viable Enzyme Through Multilayered Sealing of O 2 Tunnels"
  Opdam, L.V.; Gebhardt, P.; Leger, C.; Dobbek, H.; Fourmond, V.
  Angew Chem Int Ed Engl (65), e1942100-e1942100 (2026)
  DOI: 10.1002/anie.1942100
  PubMed ID: 42175862
  

• Structure-Guided Discovery of OAT-4828 as Potent, Selective, and Orally Bioavailable USP7 Inhibitor with In Vivo Antileukemic Activity
  Chrzanowski, J.; Nowicka, J.; Koralewski, R.; Joachimiak, L.; Gzik, A.; Borek, B.; Brzezinska, J.; Kusmirek, D.; Olejniczak, S.; Matyszewski, K.; Mazur, M.; Olczak, J.; Glatt, S.; Grudnik, P.; Wilk, P.; Muchowicz, A.; Kikulska, A.; Gluchowska, K.M.; Drzewicka, K.; Belczyk-Ciesielska, A.; Wachowska, M.; Sipak-Bujanowicz, Z.; Mulewski, K.; Tkaczyk, A.; Rejczak, T.; Golebiowski, A.; Zaslona, Z.; Blaszczyk, R.
  J Med Chem (69), 12502-12518 (2026)
  DOI: 10.1021/acs.jmedchem.6c00407
  PubMed ID: 42090583
  

• AAK1-mediated phosphorylation of PDLIM5 and Talin1 promotes focal adhesion disassembly to accelerate cell migration
  Krocianova, D.; Dagg, A.D.; Clayton, R.A.; Potesil, D.; Fedorova, V.; Harmanec, A.; Benova, V.; Bosakova, V.; Kaufman, J.G.G.; Martinkova, P.; Alblova, M.; Kelly, B.T.; Hanakova, K.; Roudnicky, P.; Spielman, S.J.; Fric, J.; Sroubek, F.; Houser, J.; Wrobel, A.G.; Boura, E.; Owen, D.J.; Zdrahal, Z.; Kadlecova, Z.
  Nat Commun (2026)
  DOI: 10.1038/s41467-026-72501-w
  PubMed ID: 42082516
  

• Structural mechanism and inhibitor discovery for DhhP, a Borrelia burgdorferi cyclic di-AMP phosphodiesterase with an Fe/Mn bimetallic center
  Klima, M.; Dejmek, M.; Palusova, A.; Chalupska, D.; Pachl, P.; Huskova, A.; Hranicek, J.; Chalupsky, K.; Moos, M.; Nencka, R.; Perner, J.; Boura, E.
  Structure (34), 758-767.e4 (2026)
  DOI: 10.1016/j.str.2026.01.016
  PubMed ID: 41742401
  

• Reprogramming of bacterial virulence by lysine acetylation
  Schmoker, O.; Girbardt, B.; Schulze, S.; Palm, G.J.; Berndt, L.; Hoppen, J.; Kara, N.; Schops, X.; Al-Abdulla, R.; Garz, K.; Junker, H.; Wolfgramm, S.; Steil, L.; Hentschker, C.; Schoknecht, K.; Mayer, L.M.; Speth, L.; Lachmayer, V.; Dorr, M.; Kemnitz, S.; Muller, S.; Lackmann, J.W.; Kruger, M.; Hofmann, K.; Bornscheuer, U.T.; Volker, U.; Kruger, E.; Kozjak-Pavlovic, V.; Lammers, M.
  Nat Commun (17) (2026)
  DOI: 10.1038/s41467-026-72244-8
  PubMed ID: 42045228
  

• Mapping the SHP2 Allosteric Pocket With Target-Biased Covalent Fragments
  Efrem, N.L.; Csorba, N.; Amoussa, M.; Abranyi-Balogh, P.; Guo, Z.; Petri, L.; Bo, F.; Di Lorenzo, V.; Roske, Y.; Szalai, T.V.; Mihalovits, L.; Simon, J.; Li, J.; Daumke, O.; Keseru, G.M.; Nazare, M.
  Chembiochem (27), e70310-e70310 (2026)
  DOI: 10.1002/cbic.70310
  PubMed ID: 42033018
  

• AcuB senses cellular energy charge to coordinate acetyl-CoA synthesis in bacteria
  Janetzky, M.; Geist, N.; Schulze, S.; Ruckert, H.; Gatzemeyer, K.; Palm, G.J.; Berndt, L.; Girbardt, B.; Weis, D.; Menyes, I.; Welsch, N.; Schweder, T.; Dorr, M.; Kemnitz, S.; Bornscheuer, U.T.; Delcea, M.; Lammers, M.
  Nat Commun (17) (2026)
  DOI: 10.1038/s41467-026-71006-w
  PubMed ID: 42031755
  

• Novel Knotted Solenoid fold with order-shifted coil arrangement leads to nontrivial 3 1 topology
  Sikora, M.; Mozajew, M.; Sikorska, J.A.; da Silva, F.B.; Perlinska, A.P.; Kluza, A.; Niewieczerzal, S.; Lukaszewicz, M.; Wielgus-Kutrowska, B.; Stachurska-Korzeniowska, K.; Jackson, S.E.; Sulkowska, J.I.
  Proc Natl Acad Sci U S A (123), e2525920123-e2525920123 (2026)
  DOI: 10.1073/pnas.2525920123
  PubMed ID: 42018416
  

• Integrative Approach to Develop and Characterize Antibodies against the Cancer-Associated Antigen Sialyl Lewis A (CA 19-9)
  Freitag, A.; Khilji, S.K.; Nedielkov, R.; M Kumar, S.; Krummhaar, M.; Arndt, J.; Moreira, G.M.S.G.; Luhle, J.; Goerdeler, F.; Kamphues, C.; Mroginski, M.A.; Roth, C.; Seeberger, P.H.; Moller, H.M.; Moscovitz, O.
  JACS Au (6), 2274-2287 (2026)
  DOI: 10.1021/jacsau.5c01596
  PubMed ID: 42063835
  

• Structural basis for allosteric regulation of mycobacterial guanosine 5 ?-monophosphate reductase by ATP and GTP
  Dolezal, M.; Knejzlik, Z.; Kouba, T.; Filimonenko, A.; Svachova, H.; Dedola, M.; Klima, M.; Pichova, I.
  Nat Commun (17) (2026)
  DOI: 10.1038/s41467-026-71657-9
  PubMed ID: 41974687
  

• N-terphenylpicolinamide derivatives designed to target PD-L1 increase activation and proliferation of T cells, and their cytotoxic properties toward cancer cells
  Muszak, D.; Kocik-Krol, J.; Zaber, J.; Kruc, O.; Palej, U.; Fijolkowska, K.; Maslanka, A.; Magiera-Mularz, K.; Plewka, J.; Stec, M.; Surmiak, M.; Szafarz, M.; Siedlar, M.; Musielak, B.; Kitel, R.; Wyska, E.; Skalniak, L.; Surmiak, E.
  Eur J Med Chem (307), 118652-118652 (2026)
  DOI: 10.1016/j.ejmech.2026.118652
  PubMed ID: 41691995
  

• A methionine-lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase
  Ringel, M.; Helmer, C.P.O.; Zev, S.; Driller, R.; Buhr, E.; Reinbold, M.; Schwartz, R.; Foley, G.; Boden, M.; Garbe, D.; Schenk, G.; Major, D.T.; Loll, B.; Bruck, T.
  FEBS Lett (2026)
  DOI: 10.1002/1873-3468.70325
  

• Fluorine-18-Labeled Nucleotide Analogs Targeting Ecto-5'-Nucleotidase (CD73) for Positron Emission Tomography Imaging of Solid Tumors
  Dobelmann, C.; Schmies, C.C.; Rolshoven, G.W.; Scortichini, M.; Wagner, S.; Isaak, A.; Idris, R.M.; Dabel, J.; Grey, L.; Losenkova, K.; Moschutz, S.; Hroub, H.A.; Keim, A.; Hoppner, S.; Sandholm, J.; Bostrom, P.; Hollmen, M.; Strater, N.; Hermann, S.; Yegutkin, G.G.; Jacobson, K.A.; Schelhaas, S.; Muller, C.E.; Junker, A.
  Angew Chem Int Ed Engl (65), e22758-e22758 (2026)
  DOI: 10.1002/anie.202522758
  PubMed ID: 41834421
  

• The planar cell polarity protein Vangl2 interacts with the PDZ-domains of Scribble but not with a unique PDZ-like domain in Inturned
  Wilmes, S.; Brysch, J.; Gelze, C.; Meier, L.; Kummel, D.
  FEBS Lett (600), 2765-2776 (2026)
  DOI: 10.1002/1873-3468.70319
  PubMed ID: 41797376
  

• Phosphatidylinositol transfer protein alpha binds microcolins in its open conformation
  Eisenreichova, A.; Klima, M.; Balla, T.; Boura, E.
  Acta Crystallogr D Struct Biol (82), 246-252 (2026)
  DOI: 10.1107/S2059798326000872
  PubMed ID: 41700428
  

• Biochemical characterization and mutational analysis of the tetrameric DABA transaminase EctB from the Arctic bacterium Marinobacter sp. CK1
  Skogvold, A.C.A.; Leiros, I.; Engh, R.A.; Erlandsen, H.
  FEBS J (293), 3545-3564 (2026)
  DOI: 10.1111/febs.70441
  PubMed ID: 41652856
  

• Achieving femtomolar affinities in structure-based drug design
  Zubriene, A.; Kurtenoka, M.; Paketuryte-Latve, V.; Leitans, J.; Manakova, E.; Zvirblis, M.; Kazaks, A.; Eimonta, V.; Tars, K.; Grazulis, S.; Petrauskas, V.; Matuliene, J.; Dudutiene, V.; Shubin, K.; Matulis, D.
  Eur Biophys J (55), 55-62 (2026)
  DOI: 10.1007/s00249-025-01812-5
  PubMed ID: 41553426
  

• Structural Interactions of beta-Lactam Antibiotics with Mammalian Serum Albumins
  Duszynski, K.; Sekula, B.; Talaj, J.; Bujacz, A.
  Int J Mol Sci (27) (2026)
  DOI: 10.3390/ijms27020776
  PubMed ID: 41596427
  

• Crystallographic Fragment Screening with CK2 alpha', an Isoform of Human Protein Kinase CK2 Catalytic Subunit, and Its Use to Obtain a CK2 alpha'/Heparin Complex Structure
  Werner, C.; Barthel, T.; Harasimowicz, H.; Marminon, C.; Weiss, M.S.; Borgne, M.L.; Niefind, K.
  Kinases Phosphatases (4), 1 (2026)
  DOI: 10.3390/kinasesphosphatases4010001
  

• Targeting of interaction between BB0323-BB0238 informs new paradigms in Lyme disease therapeutics
  Bista, S.; Brangulis, K.; Bhattachan, B.; Foor, S.D.; Ronzetti, M.H.; Jain, S.; Miller, J.; Subramanion, J.L.; Kitsou, C.; Rana, V.S.; Rai, G.; Zakharov, A.V.; Simeonov, A.; Baljinnyam, B.; Pal, U.
  PLoS Pathog (22), e1013805-e1013805 (2026)
  DOI: 10.1371/journal.ppat.1013805
  PubMed ID: 41481600
  

• Latent generative search unlocks de novo design of untapped biomolecular interactions at scale
  Didi, K.; Reidenbach, D.; Penner, M.; Ravichandran, S.; Case, M.; Nichols, M.; Swanson, E.; Reis, A.; Prescott, M.; Qian, Y.; Qian, D.; Yang, J.; Li, W.; Li, L.; Shonai, D.; Gay, S.; Mallik, B.B.; Chim, H.Y.; Chen, L.; Juanatey, M.A.; Klein, H.; Rieger, D.; Schlegel, P.; Macintyre, A.U.; Secor, M.; Granata, D.; Cha, S.; Cao, Z.; Zhou, G.; Geffner, T.; Chen, X.; Livne, M.; Zhang, Z.; Zhang, T.; Gion, K.; Bronstein, M.M.; Steinegger, M.; Deibler, K.; Soderling, S.; Schoeder, C.T.; Khmelinskaia, A.; Hollfelder, F.; Dallago, C.; Kucukbenli, E.; Vahdat, A.; Ogden, P.; Kreis, K.
  bioRxiv (2026)
  DOI: 10.64898/2026.09.12.751118
  PubMed ID: 42779796
  

• Potential 14-3-3 binding sites in sirtuins reveal extended phosphosite-recognition modes
  Weyand, M.; Quast, L.; Steegborn, C.
  Acta Crystallogr F Struct Biol Commun (82), 32-40 (2026)
  DOI: 10.1107/S2053230X25010908
  PubMed ID: 41410196
  

• Smolstatin1, a unique cystatin-like stefin of Sphaerospora molnari, is essential for parasite development
  Bartosova-Sojkova, P.; Dobai, T.; Kyslik, J.; Havlickova, P.; Vancova, M.; Picard-Sanchez, M.A.; Qadiri, S.S.N.; Martins, L.A.; Urbanova, V.; Kosakyan, A.; Bily, T.; Kale, D.; Kotal, J.; Chan, J.T.H.; Korytar, T.; Ludwig, J.; Smatanova, I.K.; Holzer, A.S.; Sojka, D.
  Curr Res Microb Sci, 100611 (2026)
  DOI: 10.1016/j.crmicr.2026.100611
  

• diFe-Sulerythin_E53D:E126D reduced
  Jeoung, J.-H.; Runger, S.; Weisser, K.; Ruickoldt, J.; Bhattacharya, S.; Limberg, C.; Dobbek, H.
  Angew Chem Int Ed Engl (2026)
  DOI: 10.1002/anie.20251918
  

• Single mutations to tyrosine or glutamate improve the crystallizability and crystal diffraction properties of a flexible two-domain protein
  Geerds, C.; Niemann, H.H.
  Acta Crystallogr F Struct Biol Commun (82), 4-13 (2026)
  DOI: 10.1107/S2053230X25010416
  PubMed ID: 41324409
  

• Fat or flat? The impact of dipole moment vectors on non-covalent interactions between aromatic tags and macromolecules
  Holub, J.; Jilkova, A.; Lemke, C.; Cianni, L.; Spiwokova, P.; Horn, M.; Breuer, C.; Leontovyc, A.; Brynda, J.; Mertlikova-Kaiserova, H.; Chanova, M.; Dos Reis Rocho, F.; Montanari, C.A.; El-Sakkary, N.; Caffrey, C.R.; Gutschow, M.; Hnyk, D.; Mares, M.; Fanfrlik, J.
  Inorg Chem Front (13), 364-376 (2026)
  DOI: 10.1039/d5qi01546d
  PubMed ID: 41127420
  

• Inhibitors of GapN-dependent NADPH supply as potential lead compounds for novel therapeutics against Streptococcus pyogenes
  Schutt, I.; Einwohlt, P.; Wandinger, A.M.; Teuffel, J.; Wirsing, R.; Hlawatschke, B.H.; Fehlauer, H.L.; Bothe, S.; Bader, N.; Monaci, E.; Kreikemeyer, B.; Schindelin, H.; Wade, R.C.; Fiedler, T.
  Virulence (17), 2609393-2609393 (2026)
  DOI: 10.1080/21505594.2025.2609393
  PubMed ID: 41437515
  

• O 2 Activation at an Enzymatic Diiron Site: Bridging Ligand Substitutions Alter Diferric-(Hydro)peroxo States
  Jeoung, J.H.; Runger, S.; Weisser, K.; Ruickoldt, J.; Bhattacharya, S.; Limberg, C.; Dobbek, H.
  Angew Chem Int Ed Engl (65), e19180-e19180 (2026)
  DOI: 10.1002/anie.202519180
  PubMed ID: 41452222
  

• Natural Product-like Fragments Unlock Novel Chemotypes for a Kinase Target?Exploring Options beyond the Flatland
  Santura, A.; Muller, J.; Wolter, M.; Tutzschky, I.C.; Ruf, M.; Metz, A.; Sandner, A.; Merkl, S.; Klebe, G.; Glinca, S.; Czodrowski, P.
  J Chem Inf Model (66), 2249-2267 (2026)
  DOI: 10.1021/acs.jcim.5c01952
  PubMed ID: 41430555
  

• Human Proteoglycan Linkage Region Glycosyltransferases are Dimeric and Show Unexpected Specificities
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